Anti-ABCB6 antibody (STJA0007484)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ABCB6
General Information
| Short Description | Rabbit polyclonal anti-ATP-binding cassette sub-family B member 6 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB6 |
| Gene ID | 10058 |
| Uniprot ID | ABCB6_HUMAN |
| Immunogen | Synthesized peptide derived from human ABCB6 |
| Specificity | This antibody detects endogenous levels of ABCB6 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 6Abc-Type Heme Transporter Abcb6Mitochondrial Abc Transporter 3Mt-Abc Transporter 3P-Glycoprotein-Related ProteinUbiquitously-Expressed Mammalian Abc Half Transporter |
| Database Links | Reactome: R-HSA-1369007Reactome: R-HSA-5683371 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion Outer MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembraneEndosome MembraneLysosome MembraneLate Endosome MembraneEarly Endosome MembraneSecretedExtracellular ExosomeMitochondrionEndosomeMultivesicular Body MembraneMelanosome MembranePresent In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid MaturationTraffics From Endoplasmic Reticulum To Golgi During Its Glycans's MaturationTherefrom Is First Targeted To The Plasma MembraneAnd Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And LysosomesLocalized On The Limiting Membrane Of Early Melanosomes Of Pigment CellsTargeted To The Endolysosomal Compartment |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 6 antibodyAnti-Abc-Type Heme Transporter Abcb6 antibodyAnti-Mitochondrial Abc Transporter 3 antibodyAnti-Mt-Abc Transporter 3 antibodyAnti-P-Glycoprotein-Related Protein antibodyAnti-Ubiquitously-Expressed Mammalian Abc Half Transporter antibodyAnti-ABCB6 antibodyAnti-MTABC3 antibodyAnti-PRP antibodyAnti-UMAT antibody |
Information sourced from Uniprot.org