Anti-ABCB6 antibody (200-250 aa) (STJ13100666)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 200-250 of human ABCB6 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCB6 (200-250 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCB6 |
| Gene ID | 10058 |
| Uniprot ID | ABCB6_HUMAN |
| Immunogen | A synthetic peptide from aa region 200-250 of human ABCB6 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 200-250 aa |
| Specificity | Specific for ABCB6. |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis. |
| Protein Name | Atp-Binding Cassette Sub-Family B Member 6Abc-Type Heme Transporter Abcb6Mitochondrial Abc Transporter 3Mt-Abc Transporter 3P-Glycoprotein-Related ProteinUbiquitously-Expressed Mammalian Abc Half Transporter |
| Database Links | Reactome: R-HSA-1369007Reactome: R-HSA-5683371 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion Outer MembraneEndoplasmic Reticulum MembraneGolgi Apparatus MembraneEndosome MembraneLysosome MembraneLate Endosome MembraneEarly Endosome MembraneSecretedExtracellular ExosomeMitochondrionEndosomeMultivesicular Body MembraneMelanosome MembranePresent In The Membrane Of Mature Erythrocytes And In Exosomes Released From Reticulocytes During The Final Steps Of Erythroid MaturationTraffics From Endoplasmic Reticulum To Golgi During Its Glycans's MaturationTherefrom Is First Targeted To The Plasma MembraneAnd Is Rapidly Internalized Through Endocytosis To Be Distributed To The Limiting Membrane Of Multivesicular Bodies And LysosomesLocalized On The Limiting Membrane Of Early Melanosomes Of Pigment CellsTargeted To The Endolysosomal Compartment |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family B Member 6 antibodyAnti-Abc-Type Heme Transporter Abcb6 antibodyAnti-Mitochondrial Abc Transporter 3 antibodyAnti-Mt-Abc Transporter 3 antibodyAnti-P-Glycoprotein-Related Protein antibodyAnti-Ubiquitously-Expressed Mammalian Abc Half Transporter antibodyAnti-ABCB6 antibodyAnti-MTABC3 antibodyAnti-PRP antibodyAnti-UMAT antibody |
Information sourced from Uniprot.org