Anti-ABCB11 antibody [SAA1534] (STJA0019962)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Bile Salt Export Pump antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1534 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | ABCB11 |
| Gene ID | 8647 |
| Uniprot ID | ABCBB_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Ubiquitinated.short-chain ubiquitination regulates cell-Surface expression of ABCB11. |
| Function | Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. |
| Protein Name | Bile Salt Export PumpAtp-Binding Cassette Sub-Family B Member 11 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-5678520 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEndosomeCell MembraneInternalized At The Canalicular Membrane Through Interaction With The Adapter Protein Complex 2 (Ap-2)At Steady StateLocalizes In The Canalicular Membrane But Is Also Present In Recycling EndosomesAbcb11 Constantly And Rapidly Exchanges Between The Two Sites Through Tubulo-Vesicles Carriers That Move Along MicrotubulesMicrotubule-Dependent Trafficking Of Abcb11 Is Enhanced By Taurocholate And Camp And Regulated By Stk11 Through A Pka-Mediated PathwayTrafficking Of Newly Synthesized Abcb11 Through Endosomal Compartment To The Bile Canalicular Membrane Is Accelerated By Camp But Not By TaurocholateCell Membrane Expression Is Up-Regulated By Short- And Medium-Chain Fatty Acids |
| Alternative Antibody Names | Anti-Bile Salt Export Pump antibodyAnti-Atp-Binding Cassette Sub-Family B Member 11 antibodyAnti-ABCB11 antibodyAnti-BSEP antibody |
Information sourced from Uniprot.org