Anti-ABCA8 antibody (400-500 aa) (STJ13100640)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 400-500 of human ABCA8 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCA8 (400-500 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCA8 |
| Gene ID | 10351 |
| Uniprot ID | ABCA8_HUMAN |
| Immunogen | A synthetic peptide from aa region 400-500 of human ABCA8 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 400-500 aa |
| Specificity | Specific for ABCA8. |
Additional Info
| Function | Isoform 1: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes. Isoform 3: Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels. |
| Protein Name | Abc-Type Organic Anion Transporter Abca8Atp-Binding Cassette Sub-Family A Member 8 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
| Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8 antibodyAnti-ABCA8 antibodyAnti-KIAA0822 antibody |
Information sourced from Uniprot.org