| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ATP-binding cassette sub-family A member 2 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCA2 |
| Gene ID: | 20 |
| Uniprot ID: | ABCA2_HUMAN |
| Specificity: | This antibody detects endogenous levels of ABCA2 at Human, Rat |
| Immunogen: | Synthesized peptide derived from human ABCA2 |
| Post Translational Modifications | Methylated at Gln-271 by N6AMT1. |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation. |
| Protein Name | Atp-Binding Cassette Sub-Family A Member 2 Atp-Binding Cassette Transporter 2 Atp-Binding Cassette 2 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Endosome Membrane Multi-Pass Membrane Protein Lysosome Membrane Forms Discrete Punctate Intracellular Vesicles |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family A Member 2 antibody Anti-Atp-Binding Cassette Transporter 2 antibody Anti-Atp-Binding Cassette 2 antibody Anti-ABCA2 antibody Anti-ABC2 antibody Anti-KIAA1062 antibody |
Information sourced from Uniprot.org