||WB, IHC-P, IF-P, ELISA
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Protein Aatf (10-90 N-Term) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||AATF polyclonal antibody (Protein Aatf) binds to endogenous Protein Aatf at the amino acid region 10-90 N-Term.
||The antiserum was produced against synthesized peptide derived from human AATF at amino acid range 10-59
| Post Translational Modifications || Hyperphosphorylated during the G1/S phase transition. |
| Function || May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Protein Name || Protein AatfApoptosis-Antagonizing Transcription FactorRb-Binding Protein Che-1 |
| Database Links || Reactome: R-HSA-193648 |
| Cellular Localisation || NucleusNucleolus |
| Alternative Antibody Names || Anti-Protein Aatf antibodyAnti-Apoptosis-Antagonizing Transcription Factor antibodyAnti-Rb-Binding Protein Che-1 antibodyAnti-AATF antibodyAnti-CHE1 antibodyAnti-DED antibodyAnti-HSPC277 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance