• Western blot analysis of lysates from HeLa cells, HepG2 cells, COLO205 cells, and HUVEC cells, using AATF Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Che-1 Polyclonal Antibody

Anti-AATF antibody (10-90 N-Term) (STJ92259)


Current Stock:
Host: Rabbit
Applications: WB, IHC-P, IF-P, ELISA
Reactivity: Human, Mouse, Rat
Short Description: Rabbit polyclonal antibody anti-Protein Aatf (10-90 N-Term) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AATF
Gene ID: 26574
Immunogen Region: 10-90 N-Term
Specificity: AATF polyclonal antibody (Protein Aatf) binds to endogenous Protein Aatf at the amino acid region 10-90 N-Term.
Immunogen: The antiserum was produced against synthesized peptide derived from human AATF at amino acid range 10-59
Post Translational Modifications Hyperphosphorylated during the G1/S phase transition.
Function May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Protein Name Protein Aatf
Apoptosis-Antagonizing Transcription Factor
Rb-Binding Protein Che-1
Database Links Reactome: R-HSA-193648
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Protein Aatf antibody
Anti-Apoptosis-Antagonizing Transcription Factor antibody
Anti-Rb-Binding Protein Che-1 antibody
Anti-AATF antibody
Anti-CHE1 antibody
Anti-DED antibody
Anti-HSPC277 antibody

Information sourced from Uniprot.org

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