| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein AATF (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AATF |
| Gene ID: | 26574 |
| Uniprot ID: | AATF_HUMAN |
| Immunogen Region: | 10-59 aa |
| Specificity: | Che-1 Polyclonal Antibody detects endogenous levels of Che-1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human the amino acidTF at the amino acid range 10-59 |
| Post Translational Modifications | Hyperphosphorylated during the G1/S phase transition. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
| Protein Name | Protein Aatf Apoptosis-Antagonizing Transcription Factor Rb-Binding Protein Che-1 |
| Database Links | Reactome: R-HSA-193648 |
| Cellular Localisation | Nucleus Nucleolus |
| Alternative Antibody Names | Anti-Protein Aatf antibody Anti-Apoptosis-Antagonizing Transcription Factor antibody Anti-Rb-Binding Protein Che-1 antibody Anti-AATF antibody Anti-CHE1 antibody Anti-DED antibody Anti-HSPC277 antibody |
Information sourced from Uniprot.org