| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Alpha-2-macroglobulin (871-920 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | A2M |
| Gene ID: | 2 |
| Uniprot ID: | A2MG_HUMAN |
| Immunogen Region: | 871-920 aa |
| Specificity: | Macroglobulin Alpha-2 Polyclonal Antibody detects endogenous levels of Macroglobulin Alpha-2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human A2M at the amino acid range 871-920 |
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-Macroglobulin Alpha-2-M C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-140837 Reactome: R-HSA-1474228 Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-2-Macroglobulin antibody Anti-Alpha-2-M antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibody Anti-A2M antibody Anti-CPAMD5 antibody Anti-FWP007 antibody |
Information sourced from Uniprot.org