Anti-A2M antibody (871-920 aa) (STJ96733)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human A2M at the amino acid range 871-920
General Information
| Short Description | Rabbit polyclonal anti-Alpha-2-macroglobulin (871-920 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | A2M |
| Gene ID | 2 |
| Uniprot ID | A2MG_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human A2M at the amino acid range 871-920 |
| Immunogen Region | 871-920 aa |
| Specificity | Macroglobulin Alpha-2 Polyclonal Antibody detects endogenous levels of Macroglobulin Alpha-2 protein. |
Additional Info
| Function | Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name | Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-2-Macroglobulin antibodyAnti-Alpha-2-M antibodyAnti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibodyAnti-A2M antibodyAnti-CPAMD5 antibodyAnti-FWP007 antibody |
Information sourced from Uniprot.org