Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-A-RAF (166-290) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Monoclonal |
Clone ID: | S8MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IHC-P 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ARAF |
Gene ID: | 369 |
Uniprot ID: | ARAF_HUMAN |
Immunogen Region: | 166-290 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-290 of human A-RAF (P10398). |
Immunogen Sequence: | RQHEAPSNRPLNELLTPQGP SPRTQHCDPEHFPFPAPANA PLQRIRSTSTPNVHMVSTTA PMDSNLIQLTGQSFSTDAAG SRGGSDGTPRGSPSPASVSS GRKSPHSKSPAEQRERKSLA DDKKK |
Tissue Specificity | Predominantly in urogenital tissues. |
Function | Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. |
Protein Name | Serine/Threonine-Protein Kinase A-Raf Proto-Oncogene A-Raf Proto-Oncogene A-Raf-1 Proto-Oncogene Pks |
Database Links | Reactome: R-HSA-5673000 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9726840 Reactome: R-HSA-9726842 |
Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase A-Raf antibody Anti-Proto-Oncogene A-Raf antibody Anti-Proto-Oncogene A-Raf-1 antibody Anti-Proto-Oncogene Pks antibody Anti-ARAF antibody Anti-ARAF1 antibody Anti-PKS antibody Anti-PKS2 antibody |
Information sourced from Uniprot.org