| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPBG |
| Gene ID: | 7162 |
| Uniprot ID: | TPBG_HUMAN |
| Immunogen Region: | 321-420 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 321-420 of human 5T4 (Q13641). |
| Immunogen Sequence: | LTCAYPEKMRNRVLLELNSA DLDCDPILPPSLQTSYVFLG IVLALIGAIFLLVLYLNRKG IKKWMHNIRDACRDHMEGYH YRYEINADPRLTNLSSNSDV |
| Tissue Specificity | Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
| Post Translational Modifications | Highly glycosylated. |
| Function | May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. |
| Protein Name | Trophoblast Glycoprotein 5t4 Oncofetal Antigen 5t4 Oncofetal Trophoblast Glycoprotein 5t4 Oncotrophoblast Glycoprotein M6p1 Wnt-Activated Inhibitory Factor 1 Waif1 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Trophoblast Glycoprotein antibody Anti-5t4 Oncofetal Antigen antibody Anti-5t4 Oncofetal Trophoblast Glycoprotein antibody Anti-5t4 Oncotrophoblast Glycoprotein antibody Anti-M6p1 antibody Anti-Wnt-Activated Inhibitory Factor 1 antibody Anti-Waif1 antibody Anti-TPBG antibody Anti-5T4 antibody |
Information sourced from Uniprot.org