Anti-5HT4 R antibody (STJ13100377)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human 5HT4 R conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-5HT4 R for use in IHC and WB in Human, Marmoset and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Marmoset/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 1000 is recommended for IHC-P and 1:2000 for WB. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | HTR4 |
| Gene ID | 3360 |
| Uniprot ID | 5HT4R_HUMAN |
| Immunogen | A synthetic peptide from human 5HT4 R conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for 5HT4 receptor. |
Additional Info
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. |
| Protein Name | 5-Hydroxytryptamine Receptor 45-Ht-45-Ht4Serotonin Receptor 4 |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneInteraction With Snx27 Mediates Recruitment To Early EndosomesWhile Interaction With Nherf1 And Ezr Might Target The Protein To Specialized Subcellular RegionsSuch As Microvilli |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 4 antibodyAnti-5-Ht-4 antibodyAnti-5-Ht4 antibodyAnti-Serotonin Receptor 4 antibodyAnti-HTR4 antibody |
Information sourced from Uniprot.org