Anti-5HT1B R antibody (STJ13100351)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse 5HT1B receptor conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-5HT1B R for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 2000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | HTR1B |
| Gene ID | 3351 |
| Uniprot ID | 5HT1B_HUMAN |
| Immunogen | A synthetic peptide from mouse 5HT1B receptor conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for 5HT1B receptor. |
Additional Info
| Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Protein Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bS12Serotonin 1d Beta Receptor5-Ht-1d-BetaSerotonin Receptor 1b |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-5-Hydroxytryptamine Receptor 1b antibodyAnti-5-Ht-1b antibodyAnti-5-Ht1b antibodyAnti-S12 antibodyAnti-Serotonin 1d Beta Receptor antibodyAnti-5-Ht-1d-Beta antibodyAnti-Serotonin Receptor 1b antibodyAnti-HTR1B antibodyAnti-HTR1DB antibody |
Information sourced from Uniprot.org