Anti-4E BP3 antibody [3B6-D3-H7] (STJA0032489)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant protein of human EIF4EBP3.
General Information
| Short Description | Mouse monoclonal anti-4E BP3 for use in WB in Transfected samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Transfected |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3B6-D3-H7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 12.1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EIF4EBP3 |
| Gene ID | 8637 |
| Uniprot ID | 4EBP3_HUMAN |
| Immunogen | Recombinant protein of human EIF4EBP3. |
Additional Info
| Tissue Specificity | Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. |
| Post Translational Modifications | Phosphorylated. |
| Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 34e-Bp3Eif4e-Binding Protein 3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 3 antibodyAnti-4e-Bp3 antibodyAnti-Eif4e-Binding Protein 3 antibodyAnti-EIF4EBP3 antibody |
Information sourced from Uniprot.org