Anti-EIF4EBP2 antibody [7A6-B3-E5] (STJ99276)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant protein of human 4E-BP2.
General Information
| Short Description | Mouse monoclonal anti-Eukaryotic translation initiation factor 4E-binding protein 2 for use in WB in Transfected samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Transfected |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7A6-B3-E5 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EIF4EBP2 |
| Gene ID | 1979 |
| Uniprot ID | 4EBP2_HUMAN |
| Immunogen | Recombinant protein of human 4E-BP2. |
| Specificity | Transfected Only. |
Additional Info
| Function | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Protein Name | Eukaryotic Translation Initiation Factor 4e-Binding Protein 24e-Bp2Eif4e-Binding Protein 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 2 antibodyAnti-4e-Bp2 antibodyAnti-Eif4e-Binding Protein 2 antibodyAnti-EIF4EBP2 antibody |
Information sourced from Uniprot.org