• Western blot detection of 4E-BP2 in CHO-K1 cell lysate (A) and CHO-K1 transfected by EGFP-4E-BP2 (B) cell lysate using 4E-BP2 mouse mAb (1:1000 diluted).

Anti-EIF4EBP2 antibody [7A6-B3-E5] (STJ99276)

SKU:
STJ99276

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB
Reactivity: Transfected
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Eukaryotic translation initiation factor 4E-binding protein 2 is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: 7A6-B3-E5
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EIF4EBP2
Gene ID: 1979
Uniprot ID: 4EBP2_HUMAN
Specificity: Transfected Only.
Immunogen: Recombinant protein of human 4E-BP2.
Function Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Protein Name Eukaryotic Translation Initiation Factor 4e-Binding Protein 2
4e-Bp2
Eif4e-Binding Protein 2
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 2 antibody
Anti-4e-Bp2 antibody
Anti-Eif4e-Binding Protein 2 antibody
Anti-EIF4EBP2 antibody

Information sourced from Uniprot.org

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