Anti-15 PGDH antibody (STJA0037808)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human 15-PGDH
General Information
| Short Description | Rabbit monoclonal anti-15 PGDH for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HPGD |
| Gene ID | 3248 |
| Uniprot ID | PGDH_HUMAN |
| Immunogen | Recombinant protein of human 15-PGDH |
Additional Info
| Tissue Specificity | Detected in colon epithelium (at protein level). |
| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation. |
| Protein Name | 15-Hydroxyprostaglandin Dehydrogenase Nad(+15-PgdhEicosanoid/Docosanoid Dehydrogenase Nad(+Prostaglandin Dehydrogenase 1Short Chain Dehydrogenase/Reductase Family 36c Member 1 |
| Database Links | Reactome: R-HSA-2142700Reactome: R-HSA-2162123Reactome: R-HSA-9018676Reactome: R-HSA-9018896 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-15-Hydroxyprostaglandin Dehydrogenase Nad(+ antibodyAnti-15-Pgdh antibodyAnti-Eicosanoid/Docosanoid Dehydrogenase Nad(+ antibodyAnti-Prostaglandin Dehydrogenase 1 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 36c Member 1 antibodyAnti-HPGD antibodyAnti-PGDH1 antibodyAnti-SDR36C1 antibody |
Information sourced from Uniprot.org