Anti-14-3-3 theta antibody [R07-8G4] (STJA0033964)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human 14-3-3 Theta/Tau
General Information
| Short Description | Rabbit monoclonal anti-14-3-3 theta for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-8G4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | YWHAQ |
| Gene ID | 10971 |
| Uniprot ID | 1433T_HUMAN |
| Immunogen | A synthetic peptide of human 14-3-3 Theta/Tau |
Additional Info
| Tissue Specificity | Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. |
| Post Translational Modifications | Ser-232 is probably phosphorylated by CK1. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
| Protein Name | 14-3-3 Protein Theta14-3-3 Protein T-Cell14-3-3 Protein TauProtein Hs1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmIn NeuronsAxonally Transported To The Nerve Terminals |
| Alternative Antibody Names | Anti-14-3-3 Protein Theta antibodyAnti-14-3-3 Protein T-Cell antibodyAnti-14-3-3 Protein Tau antibodyAnti-Protein Hs1 antibodyAnti-YWHAQ antibody |
Information sourced from Uniprot.org