Anti-14-3-3 theta antibody (1-245aa) [AT1A1] (STJA0041555)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human 14-3-3 tau (1-245aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-14-3-3 theta (1-245aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1A1 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | YWHAQ |
| Gene ID | 10971 |
| Uniprot ID | 1433T_HUMAN |
| Accession Number | NP_006817 |
| Immunogen | Recombinant human 14-3-3 tau (1-245aa) purified from E. coli |
| Immunogen Region | 1-245aa |
Additional Info
| Tissue Specificity | Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. |
| Post Translational Modifications | Ser-232 is probably phosphorylated by CK1. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. |
| Protein Name | 14-3-3 Protein Theta14-3-3 Protein T-Cell14-3-3 Protein TauProtein Hs1 |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmIn NeuronsAxonally Transported To The Nerve Terminals |
| Alternative Antibody Names | Anti-14-3-3 Protein Theta antibodyAnti-14-3-3 Protein T-Cell antibodyAnti-14-3-3 Protein Tau antibodyAnti-Protein Hs1 antibodyAnti-YWHAQ antibody |
Information sourced from Uniprot.org