Anti-14-3-3 alpha+beta antibody [SM5110] (STJA0005110)

Name: Anti-14-3-3 alpha+beta antibody [SM5110] (STJA0005110)
SKU: STJA0005110
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostMouse

ConjugationUnconjugated

IsotypeIgG

ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse 14-3-3 alpha + beta

STJA0005110

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Short Description	Mouse monoclonal anti-14-3-3 alpha+beta for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	IHC/IF
Host	Mouse
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	SM5110
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity purification
Dilution Range	IHC/IF (H, M, R) 1:500-1:1000/1:500-1:1000
Formulation	PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol.
Storage Instruction	Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.

Gene Symbol	Ywhab
Gene ID	54401
Uniprot ID	1433B_MOUSE
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse 14-3-3 alpha + beta

Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
Protein Name	14-3-3 Protein Beta/Alpha Protein Kinase C Inhibitor Protein 1 Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed
Database Links	Reactome: R-MMU-111447 Reactome: -MMU-165159 Reactome: -MMU-166208 Reactome: -MMU-170968 Reactome: -MMU-2028269 Reactome: -MMU-392517 Reactome: -MMU-450385 Reactome: -MMU-450513 Reactome: -MMU-5625740 Reactome: -MMU-5628897 Reactome: -MMU-5673000 Reactome: -MMU-5674135 Reactome: -MMU-5675221 Reactome: -MMU-75035 Reactome: -MMU-9614399
Cellular Localisation	Cytoplasm Melanosome
Alternative Antibody Names	Anti-14-3-3 Protein Beta/Alpha antibody Anti-Protein Kinase C Inhibitor Protein 1 antibody Anti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibody Anti-Ywhab antibody

Information sourced from Uniprot.org