alpha Actinin 4 Blocking Peptide for STJ502088 peptide (STJ503627)
General Information
| Short Description | alpha Actinin 4 Blocking Peptide for STJ502088 is synthetically produced from the 140-190 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ACTN4 |
| Gene ID | 81 |
| Uniprot ID | ACTN4_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 140-190 on human Alpha Actinin 4 protein. |
| Immunogen Region | 140-190 |
| Specificity | This blocking peptide is recommended for use in combination with alpha Actinin 4 antibody, STJ502088 |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation. |
| Peptide Name | Alpha-Actinin-4Non-Muscle Alpha-Actinin 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753 |
| Cellular Localisation | NucleusCytoplasmCell JunctionCytoskeletonStress FiberPerinuclear RegionLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasExpressed In The Perinuclear Rim And Manchette Structure In Early Elongating Spermatids During SpermiogenesisNuclear Translocation Can Be Induced By The Pi3 Kinase Inhibitor Wortmannin Or By Cytochalasin DExclusively Localized In The Nucleus In A Limited Number Of Cell Lines (Breast Cancer Cell Line Mcf-7Oral Floor Cancer Imc-2And Bladder Cancer Ku-7) |
| Alternative Peptide Names | Alpha-Actinin-4 proteinNon-Muscle Alpha-Actinin 4 proteinACTN4 protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about alpha Actinin 4 Blocking Peptide for STJ502088 peptide (STJ503627)
STJ503627 is a blocking peptide intended for use in combination with the alpha Actinin 4 antibody STJ502088. It is used as a specificity control in immunodepletion or immunocompetition experiments to confirm that the antibody signal is target-specific.
This blocking peptide is a synthetic peptide derived from amino acid region 140 to 190 of the human Alpha Actinin 4 protein, corresponding to UniProt accession O43707.
This product is recommended for immunodepletion and immunocompetition applications only. It is intended for research use only and is not validated for diagnostic or therapeutic purposes.
This blocking peptide is supplied in liquid form at 2.5 mg/ml in PBS, with the option to add up to 5% DMSO. Orders exceeding 1 mg can be supplied in lyophilized powder form or reconstituted in a buffer of choice.
This product should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.