ImmunogenSynthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH. Sequence: DERKTAWGERNGQKR
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ADCY6 Blocking Peptide for STJ502072 is synthetically produced from the 13-27 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH. Sequence: DERKTAWGERNGQKR
Immunogen Region
13-27
Specificity
This blocking peptide is recommended for use in combination with ADCY6 antibody, STJ502072
Additional Info
Tissue Specificity
Detected in brain and kidney. Detected in vascular smooth muscle cells.
Post Translational Modifications
Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity.
Function
Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Peptide Name
Adenylate Cyclase Type 6Atp Pyrophosphate-Lyase 6Adenylate Cyclase Type ViAcviAdenylyl Cyclase 6Ac6Ca(2+-Inhibitable Adenylyl Cyclase
