| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TNK1 Positive Control for STJ506145 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TNK1 |
| Gene ID: |
8711 |
| Uniprot ID: |
TNK1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with TNK1 antibody STJ506145. |
| Tissue Specificity | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
| Post Translational Modifications | Autophosphorylated on tyrosine residues. |
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Peptide Name | Non-Receptor Tyrosine-Protein Kinase Tnk1Cd38 Negative Kinase 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Peptide Names | Non-Receptor Tyrosine-Protein Kinase Tnk1 proteinCd38 Negative Kinase 1 proteinTNK1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
