| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TNIK Blocking Peptide for STJ503344 is synthetically produced from the 1250-1300 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TNIK |
| Gene ID: |
23043 |
| Uniprot ID: |
TNIK_HUMAN |
| Immunogen Region: |
1250-1300 |
| Specificity: |
This blocking peptide is recommended for use in combination with TNIK antibody, STJ503344 |
| Immunogen: |
Sythetic peptide taken within amino acid region 1250-1300 on human TRAF2 and NCK-interacting protein kinase protein. |
| Tissue Specificity | Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. |
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. |
| Function | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. |
| Peptide Name | Traf2 And Nck-Interacting Protein Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | NucleusCytoplasmRecycling EndosomeCytoskeletonAssociated With Recycling Endosomes And The Cytoskeletal Fraction Upon Rap2a Overexpression |
| Alternative Peptide Names | Traf2 And Nck-Interacting Protein Kinase proteinTNIK proteinKIAA0551 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
