Syncytin 2 Blocking Peptide for STJ503173 is synthetically produced from the 380-430 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 380-430 on mouse Envelope glycoprotein syncytin-B protein.
Immunogen Region
380-430
Specificity
This blocking peptide is recommended for use in combination with Syncytin 2 antibody, STJ503173
Additional Info
Tissue Specificity
Highly expressed in placenta where it localizes to syncytiotrophoblasts of the labyrinthine zona. Specifically localizes to syncytiotrophoblast layer II (SynT-II). Also detected at very low levels in ovary.
Post Translational Modifications
Synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence KR-X-KR-R. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
Function
This endogenous retroviral envelope protein has retained its original fusogenic properties. Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males. May have immunosuppressive activity.
Peptide Name
Syncytin-B Cleaved Into - Surface ProteinSu - Transmembrane ProteinTm
Cellular Localisation
Surface Protein: Cell MembranePeripheral Membrane ProteinThe Surface Protein Is Not Anchored To The MembraneBut Localizes To The Extracellular Surface Through Its Binding To TmTransmembrane Protein: Cell MembraneSingle-Pass Membrane Protein
Alternative Peptide Names
Syncytin-B Cleaved Into - Surface Protein proteinSu - Transmembrane Protein proteinTm proteinSynb protein
