| Host: | Rabbit/Rabbit |
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This IL-1R1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality : | Polyclonal/Polyclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Protein A & Antigen Affinity. Detection Purification: Protein A & Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | Il1r1 |
| Uniprot ID: | IL1R1_RAT |
| Immunogen: | Capture immunogen: Recombinant Rat IL-1R1 protein. Detection Immunogen: Recombinant Rat IL-1R1 protein. |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
| Protein Name | Interleukin-1 Receptor Type 1 Il-1r-1 Il-1rt-1 Il-1rt1 Cd121 Antigen-Like Family Member A Interleukin-1 Receptor Alpha Il-1r-Alpha Interleukin-1 Receptor Type I P80 Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form Mil-1r1 Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form Sil-1r1 Sil-1ri |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Cell Membrane Secreted |
| Alternative Antibody Pair Names | Interleukin-1 Receptor Type 1 antibody pair Il-1r-1 antibody pair Il-1rt-1 antibody pair Il-1rt1 antibody pair Cd121 Antigen-Like Family Member A antibody pair Interleukin-1 Receptor Alpha antibody pair Il-1r-Alpha antibody pair Interleukin-1 Receptor Type I antibody pair P80 antibody pair Cd Antigen Cd121a Cleaved Into - Interleukin-1 Receptor Type 1 - Membrane Form antibody pair Mil-1r1 antibody pair Mil-1ri - Interleukin-1 Receptor Type 1 - Soluble Form antibody pair Sil-1r1 antibody pair Sil-1ri antibody pair Il1r1 antibody pair Il1ra antibody pair |
Information sourced from Uniprot.org