| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.001 EU/Mu g |
| Immunoreactivity: | Measured in a cell proliferation assay using Mv.1.lu cells. The ED50 for this effect is 1.6-6.2 ng/mL, corresponding to a specific activity of 1.6×105~6.3×105 units/mg. |
| Gene Symbol: | Hgf |
| Gene ID: | 24446 |
| Uniprot ID: | HGF_RAT |
| Immunogen Region: | Gln 33-Leu728 |
| Immunogen: | Recombinant Rat Hepatocyte growth factor/HGF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln 33-Leu728) of rat HGF (Accession #NP_058713.1) fused with and a 6×His tag at the C-terminus. |
| Immunogen Sequence: | MQGPRTRPRKPIRCGEVLFA VGGWCSGDAISSVERYDPQT NEWRMVASMSKRRCGVGVSV LDDLLYAVGGHDGSSYLNSV ERYDPKTNQWSSDVAPTSTC RTSVGVAVLGGFLYAVGGQD GVSCLNIVERYDPKENKWTR VASMSTRRLGVAVAVLGGFL YAVGGSDGTSPLNTVERYNP QENRWHTIAPMGTRRKHLGC AVYQDMIYAVGGRDDTTELS SAERYNPRTNQWSPVVAMT |
| Post Translational Modifications | The single-chain precursor undergoes proteolytic processing by TMPRSS13 resulting in an active two-chain form. |
| Function | Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation. |
| Protein Name | Hepatocyte Growth FactorHepatopoietin-AScatter FactorSf Cleaved Into - Hepatocyte Growth Factor Alpha Chain - Hepatocyte Growth Factor Beta Chain |
| Database Links | Reactome: R-RNO-114608Reactome: -RNO-1257604Reactome: -RNO-5673001Reactome: -RNO-6806942Reactome: -RNO-6807004Reactome: -RNO-6811558Reactome: -RNO-8851805Reactome: -RNO-8851907Reactome: -RNO-8865999Reactome: -RNO-8874081Reactome: -RNO-8875513Reactome: -RNO-8875555Reactome: -RNO-8875656Reactome: -RNO-8875791Reactome: -RNO-9734091 |
| Alternative Protein Names | Hepatocyte Growth Factor proteinHepatopoietin-A proteinScatter Factor proteinSf Cleaved Into - Hepatocyte Growth Factor Alpha Chain - Hepatocyte Growth Factor Beta Chain proteinHgf protein |
Information sourced from Uniprot.org