| Tissue Specificity | Expressed in the CA1 region of the hippocampus, expression decreases with age (at protein level). Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis. |
| Post Translational Modifications | Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. |
| Function | Isoform 1: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 2: Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. Isoform 3: Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 4: Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. |
| Protein Name | Estrogen Receptor BetaEr-BetaNuclear Receptor Subfamily 3 Group A Member 2 |
| Database Links | Reactome: R-RNO-1257604Reactome: -RNO-383280Reactome: -RNO-6811558Reactome: -RNO-8939211Reactome: -RNO-9009391 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Estrogen Receptor Beta ELISA kitEr-Beta ELISA kitNuclear Receptor Subfamily 3 Group A Member 2 ELISA kitEsr2 ELISA kitErbeta ELISA kitNr3a2 ELISA kit |
| output | |
Information sourced from Uniprot.org
