Rat EDN1 (Endothelin 1) Competitive ELISA Kit Ready-To-Use Kit (STJE0014953)

Rat EDN1 (Endothelin 1) Competitive ELISA Kit Ready-To-Use Kit (STJE0014953)

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STJE0014953
€457.80 - €634.20
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Short Description :This EDN1 Competitive ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids..
Applications:ELISA
Reactivity:Rat
Sensitivity:2.19pg/mL
Detection Limit:7.81-500pg/mL
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Storage Instruction:The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:2.5 hrs
Gene Symbol:Edn1
Gene ID:24323
Uniprot ID:EDN1_RAT
Immunogen Region:Ready-To-Use
Sample Type:serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.
Protein Name Endothelin-1
Et-1
Preproendothelin-1
Ppet1 Cleaved Into - Big Endothelin-1
Database Links Reactome: R-RNO-375276
Reactome: -RNO-416476
Cellular Localisation Secreted
Alternative ELISA Names Endothelin-1 ELISA kit
Et-1 ELISA kit
Preproendothelin-1 ELISA kit
Ppet1 Cleaved Into - Big Endothelin-1 ELISA kit
Edn1 ELISA kit
output

Information sourced from Uniprot.org

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