| Host: |
HEK293 cells |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Rat CCL2/MCP-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Gene Symbol: |
Ccl2 |
| Gene ID: |
24770 |
| Uniprot ID: |
CCL2_RAT |
| Immunogen: |
Recombinant Rat CCL2/MCP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Asn148) of rat CCL2/JE/MCP-1 (Accession #NP_113718.1.) fused with a 6×His tag at the C-terminus. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
| Protein Name | C-C Motif Chemokine 2Immediate-Early Serum-Responsive Protein JeMonocyte Chemoattractant Protein 1Monocyte Chemotactic Protein 1Mcp-1Small-Inducible Cytokine A2 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 proteinImmediate-Early Serum-Responsive Protein Je proteinMonocyte Chemoattractant Protein 1 proteinMonocyte Chemotactic Protein 1 proteinMcp-1 proteinSmall-Inducible Cytokine A2 proteinCcl2 proteinJe proteinMcp1 proteinScya2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
