| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Presenilin 2 Blocking Peptide is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PSEN2 |
| Gene ID: |
5664 |
| Uniprot ID: |
PSN2_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein. |
| Tissue Specificity | Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
| Post Translational Modifications | Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues. |
| Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
| Peptide Name | Presenilin-2Ps-2Ad3lpAd5E5-1Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Peptide Names | Presenilin-2 proteinPs-2 proteinAd3lp proteinAd5 proteinE5-1 proteinStm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit proteinPSEN2 proteinAD4 proteinPS2 proteinPSNL2 proteinSTM2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
