| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-Phospholipase A2 Blocking Peptide is synthetically produced from the 450-500 sequence and is suitable for use in western blot applications. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PLAA |
| Gene ID: |
9373 |
| Uniprot ID: |
PLAP_HUMAN |
| Immunogen Region: |
450-500 |
| Immunogen: |
Synthetic peptide taken within amino acid region 450-500 on human Phospholipase A2-activating protein. |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Peptide Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Peptide Names | Phospholipase A-2-Activating Protein proteinPla2p proteinPlap proteinPLAA proteinPLAP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
