| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PDE4A1 Positive Control for STJ502283 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Pde4a |
| Gene ID: |
25638 |
| Uniprot ID: |
PDE4A_RAT |
| Specificity: |
This is positive control is recommended for use in combination with PDE4A1 antibody STJ502283. |
| Tissue Specificity | Isoform 2: Isoform 2 is testis specific. |
| Post Translational Modifications | Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. |
| Peptide Name | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4aDpde2 |
| Database Links | Reactome: R-RNO-180024Reactome: -RNO-418555 |
| Cellular Localisation | Isoform 2: CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Peptide Names | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4a proteinDpde2 proteinPde4a protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
