PDE4A1 Positive Control for STJ502283 peptide (STJ504619)

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STJ504619-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PDE4A1 Positive Control for STJ502283 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Pde4a
Gene ID: 25638
Uniprot ID: PDE4A_RAT
Specificity: This is positive control is recommended for use in combination with PDE4A1 antibody STJ502283.
Tissue Specificity Isoform 2: Isoform 2 is testis specific.
Post Translational Modifications Isoform 1: Phosphorylated by MAPKAPK2 at Ser-147.it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling. Proteolytically cleaved by CASP3.
Function Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP.
Peptide Name 3' -5'-Cyclic-Amp Phosphodiesterase 4a
Dpde2
Camp-Specific Phosphodiesterase 4a
Database Links Reactome: R-RNO-180024
Reactome: -RNO-418555
Cellular Localisation Isoform 2: Cytoplasm
Cytosol
Membrane
Peripheral Membrane Protein
Alternative Peptide Names 3' -5'-Cyclic-Amp Phosphodiesterase 4a protein
Dpde2 protein
Camp-Specific Phosphodiesterase 4a protein
Pde4a protein

Information sourced from Uniprot.org

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