| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-PDE3A Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
| Peptide Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3aCyclic Gmp-Inhibited Phosphodiesterase ACgi-Pde A |
| Database Links | Reactome: R-MMU-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytosol |
| Alternative Peptide Names | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a proteinCyclic Gmp-Inhibited Phosphodiesterase A proteinCgi-Pde A proteinPde3a protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
