PDE2A2 Blocking Peptide peptide (STJ505340)

SKU:
STJ505340-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE2A2 Blocking Peptide is synthetically produced from the 1-50 aa sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE2A
Gene ID: 5138
Uniprot ID: PDE2A_HUMAN
Immunogen Region: 1-50 aa
Immunogen: Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A2 protein.
Tissue Specificity Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Function cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Peptide Name Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase
Cyclic Gmp-Stimulated Phosphodiesterase
Cgs-Pde
Cgspde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Isoform Pde2a3: Cell Membrane
Lipid-Anchor
Isoform Pde2a2: Mitochondrion Matrix
Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Isoform Pde2a1: Cytoplasm
Isoform 5: Mitochondrion
Alternative Peptide Names Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase protein
Cyclic Gmp-Stimulated Phosphodiesterase protein
Cgs-Pde protein
Cgspde protein
PDE2A protein

Information sourced from Uniprot.org

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