NeuroD1 Blocking Peptide for STJ506339 peptide (STJ506342)

SKU:
STJ506342-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: NeuroD1 Blocking Peptide for STJ506339 is synthetically produced from the 300-356 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NEUROD1
Gene ID: 4760
Uniprot ID: NDF1_HUMAN
Immunogen Region: 300-356
Specificity: This blocking peptide is recommended for use in combination with NeuroD1 antibody, STJ506339
Post Translational Modifications Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation.which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335.which promotes dendritic growth. Phosphorylated by MAPK1.phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells.
Function Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
Peptide Name Neurogenic Differentiation Factor 1
Neurod
Neurod1
Class A Basic Helix-Loop-Helix Protein 3
Bhlha3
Database Links Reactome: R-HSA-210745
Reactome: R-HSA-210746
Cellular Localisation Cytoplasm
Nucleus
In Pancreatic Islet Cells
Shuttles To The Nucleus In Response To Glucose Stimulation
Colocalizes With Nr0b2 In The Nucleus
Alternative Peptide Names Neurogenic Differentiation Factor 1 protein
Neurod protein
Neurod1 protein
Class A Basic Helix-Loop-Helix Protein 3 protein
Bhlha3 protein
NEUROD1 protein
BHLHA3 protein
NEUROD protein

Information sourced from Uniprot.org

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