| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Neurochondrin Blocking Peptide for STJ501950 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Ncdn |
| Gene ID: |
89791 |
| Uniprot ID: |
NCDN_RAT |
| Specificity: |
This blocking peptide is recommended for use in combination with Neurochondrin antibody, STJ501950 |
| Immunogen: |
Synthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein. |
| Tissue Specificity | Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites. |
| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. |
| Function | Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. |
| Peptide Name | NeurochondrinNeurite Outgrowth-Related Protein From The Rat BrainNorbin |
| Cellular Localisation | CytoplasmCytosolEndosome MembraneLipid-AnchorCell ProjectionDendritePostsynapseLocalizes To Somatic Regions Of NeuronsLocalization To Endosome Membrane Requires Palmitoylation |
| Alternative Peptide Names | Neurochondrin proteinNeurite Outgrowth-Related Protein From The Rat Brain proteinNorbin proteinNcdn protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
