| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.53ng/mL |
| Detection Limit: |
1.56-100ng/mL |
| Short Description: |
This VLDLR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Vldlr |
| Gene ID: |
22359 |
| Uniprot ID: |
VLDLR_MOUSE |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | Abundant in heart and muscle.less in kidney, brain, ovary, testis, lung and adipose tissue. Strongly expressed in neurons. |
| Post Translational Modifications | Ubiquitinated at Lys-839 by MYLIP leading to degradation. |
| Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone. |
| Protein Name | Very Low-Density Lipoprotein ReceptorVldl ReceptorVldl-R |
| Database Links | Reactome: R-MMU-8866376Reactome: -MMU-8866427Reactome: -MMU-8964046 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinClathrin-Coated Pit |
| Alternative ELISA Names | Very Low-Density Lipoprotein Receptor ELISA kitVldl Receptor ELISA kitVldl-R ELISA kitVldlr ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
