Mouse PXR (Pregnane X Receptor) Sandwich ELISA Kit (STJE0011783)
SPECIFICATIONS
General Information
| Short Description | This PXR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.049ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Nr1i2 |
| Gene ID | 18171 |
| Uniprot ID | NR1I2_MOUSE |
| Sample Type | tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN). |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor PxrPregnane X Receptor |
| Database Links | Reactome: R-MMU-383280Reactome: -MMU-4090294 |
| Cellular Localisation | Nucleus |
| Alternative ELISA Names | Nuclear Receptor Subfamily 1 Group I Member 2 ELISA kitOrphan Nuclear Receptor Pxr ELISA kitPregnane X Receptor ELISA kitNr1i2 ELISA kitPxr ELISA kit |
| output |
Information sourced from Uniprot.org