Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
Protein Name | Glutamate Carboxypeptidase 2Folate Hydrolase 1Folylpoly-Gamma-Glutamate CarboxypeptidaseFgcpGlutamate Carboxypeptidase IiGcpiiMembrane Glutamate CarboxypeptidaseMgcpN-Acetylated-Alpha-Linked Acidic Dipeptidase INaaladase IProstate-Specific Membrane Antigen HomologPteroylpoly-Gamma-Glutamate Carboxypeptidase |
Database Links | Reactome: R-MMU-8963693 |
Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
Alternative Protein Names | Glutamate Carboxypeptidase 2 proteinFolate Hydrolase 1 proteinFolylpoly-Gamma-Glutamate Carboxypeptidase proteinFgcp proteinGlutamate Carboxypeptidase Ii proteinGcpii proteinMembrane Glutamate Carboxypeptidase proteinMgcp proteinN-Acetylated-Alpha-Linked Acidic Dipeptidase I proteinNaaladase I proteinProstate-Specific Membrane Antigen Homolog proteinPteroylpoly-Gamma-Glutamate Carboxypeptidase proteinFolh1 proteinMopsm proteinNaalad1 protein |
Information sourced from Uniprot.org