| Host: | Rabbit/Rabbit |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This LDLR antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality : | Polyclonal/Polyclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Protein A & Antigen Affinity.Detection Purification: Protein A & Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | Ldlr |
| Gene ID: | 16835 |
| Uniprot ID: | LDLR_MOUSE |
| Immunogen: | Capture immunogen: Recombinant Mouse LDLR protein.Detection Immunogen: Recombinant Mouse LDLR protein. |
| Function | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. |
| Protein Name | Low-Density Lipoprotein ReceptorLdl Receptor |
| Database Links | Reactome: R-MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-8964026Reactome: -MMU-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneClathrin-Coated PitGolgi ApparatusEarly EndosomeLate EndosomeLysosomeRapidly Endocytosed Upon Ligand Binding |
| Alternative Antibody Pair Names | Low-Density Lipoprotein Receptor antibody pairLdl Receptor antibody pairLdlr antibody pair |
Information sourced from Uniprot.org
