| Tissue Specificity | Expressed in lymphoid organs and in cell lines of hemopoietic origin. |
| Post Translational Modifications | Phosphorylation at Tyr-228 and Tyr-257 activates it. May be phosphorylated by LCK. N-glycosylated. |
| Function | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. |
| Protein Name | Leukocyte-Associated Immunoglobulin-Like Receptor 1Lair-1Mlair1Cd Antigen Cd305 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte-Associated Immunoglobulin-Like Receptor 1 proteinLair-1 proteinMlair1 proteinCd Antigen Cd305 proteinLair1 protein |
Information sourced from Uniprot.org
