| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1.0 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Il5ra |
| Gene ID: | 16192 |
| Uniprot ID: | IL5RA_MOUSE |
| Immunogen: | Recombinant Mouse IL-5RA/CD125 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp18-His339) of mouse IL5RA/CD125 (Accession #NP_032396.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | DLLNHKKFLLLPPVNFTIKA TGLAQVLLHWDPNPDQEQRH VDLEYHVKINAPQEDEYDTR KTESKCVTPLHEGFAASVRT ILKSSHTTLASSWVSAELKA PPGSPGTSVTNLTCTTHTVV SSHTHLRPYQVSLRCTWLVG KDAPEDTQYFLYYRFGVLTE KCQEYSRDALNRNTACWFPR TFINSKGFEQLAVHINGSSK RAAIKPFDQLFSPLAIDQVN PPRNVTVEIESNSLYIQWE |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCd Antigen Cd125 |
| Database Links | Reactome: R-MMU-512988Reactome: -MMU-5673001Reactome: -MMU-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-5 Receptor Subunit Alpha proteinIl-5 Receptor Subunit Alpha proteinIl-5r Subunit Alpha proteinIl-5r-Alpha proteinIl-5ra proteinCd Antigen Cd125 proteinIl5ra proteinIl5r protein |
Information sourced from Uniprot.org