| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL-5RA/CD125-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
Il5ra |
| Gene ID: |
16192 |
| Uniprot ID: |
IL5RA_MOUSE |
| Immunogen: |
Recombinant Mouse IL-5RA/CD125 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp18-His339) of mouse IL5RA/CD125 (Accession #NP_032396.1) fused with a 6×His tag at the C-terminus. |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCd Antigen Cd125 |
| Database Links | Reactome: R-MMU-512988Reactome: -MMU-5673001Reactome: -MMU-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-5 Receptor Subunit Alpha proteinIl-5 Receptor Subunit Alpha proteinIl-5r Subunit Alpha proteinIl-5r-Alpha proteinIl-5ra proteinCd Antigen Cd125 proteinIl5ra proteinIl5r protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
