| Function | Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning. Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6. |
| Protein Name | Interleukin-4Il-4B-Cell Igg Differentiation FactorB-Cell Growth Factor 1B-Cell Stimulatory Factor 1Bsf-1Igg1 Induction FactorLymphocyte Stimulatory Factor 1 |
| Database Links | Reactome: R-MMU-6785807 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-4 antibody pairIl-4 antibody pairB-Cell Igg Differentiation Factor antibody pairB-Cell Growth Factor 1 antibody pairB-Cell Stimulatory Factor 1 antibody pairBsf-1 antibody pairIgg1 Induction Factor antibody pairLymphocyte Stimulatory Factor 1 antibody pairIl4 antibody pairIl-4 antibody pair |
Information sourced from Uniprot.org
