Mouse IL-12 p40 (IL-12 p40) Antibody Pair (STJAP00739)
General Information
| Short Description | This IL-12 p40 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R03-1X8/R02-6Z7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Il12b |
| Gene ID | 16160 |
| Uniprot ID | IL12B_MOUSE |
| Immunogen | Recombinant protein |
Additional Info
| Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
| Protein Name | Interleukin-12 Subunit BetaIl-12bCytotoxic Lymphocyte Maturation Factor 40 Kda SubunitClmf P40Il-12 Subunit P40 |
| Database Links | Reactome: R-MMU-9020591Reactome: -MMU-9020933 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Interleukin-12 Subunit Beta antibody pairIl-12b antibody pairCytotoxic Lymphocyte Maturation Factor 40 Kda Subunit antibody pairClmf P40 antibody pairIl-12 Subunit P40 antibody pairIl12b antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse IL-12 p40 (IL-12 p40) Antibody Pair (STJAP00739)
This antibody pair detects mouse IL-12 p40, the shared subunit of IL-12 and IL-23, with reactivity confirmed for mouse. The target corresponds to UniProt entry P43432.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2. Clone IDs are R03-1X8 and R02-6Z7, and both are affinity purified.
This pair is validated for ELISA. No other assay formats are listed for this product.
Optimal working concentrations are determined by the end user and are not pre-defined in the product specifications. Titration experiments are recommended to establish the appropriate dilution for each antibody in the specific assay setup.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies were raised against a recombinant protein immunogen corresponding to mouse IL-12 p40. No further detail on the immunogen region is specified in the product information.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.