• Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)
  • Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)
  • Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)
  • Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)
  • Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)
  • Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)

Mouse IL-1 beta protein (Recombinant) (C-His) (STJP001329)

SKU:
STJP001329

Current Stock:
Host: E. coli
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IL-1 beta-C-His protein was developed from e. coli and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse IL1B at 10 Mu g/mL (100 Mu L/well) can bind Human IL1R2 with a linear range of 0.03125-0.8036 Mu g/mL.2. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cel
Gene Symbol: Il1b
Gene ID: 16176
Uniprot ID: IL1B_MOUSE
Immunogen Region: Val118-Ser269
Immunogen: Active Recombinant Mouse IL-1 beta Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val118-Ser269) of mouse IL-1 beta (Accession #NP_032387.1) fused with 6Ă—His tag at the C-terminus.
Tissue Specificity Expressed in activated macrophages (at protein level).
Function Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Protein Name Interleukin-1 Beta
Il-1 Beta
Database Links Reactome: R-MMU-448706
Reactome: -MMU-5620971
Reactome: -MMU-5660668
Reactome: -MMU-9020702
Cellular Localisation Cytoplasm
Cytosol
Secreted
Lysosome
Extracellular Exosome
The Precursor Is Cytosolic
In Response To Inflammasome-Activating Signals
Such As Atp For Nlrp3 Inflammasome Or Bacterial Flagellin For Nlrc4 Inflammasome
Cleaved And Secreted
Mature Form Is Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore
In Contrast
The Precursor Form Is Not Released
Due To The Presence Of An Acidic Region That Is Proteolytically Removed By Casp1 During Maturation
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
Alternative Protein Names Interleukin-1 Beta protein
Il-1 Beta protein
Il1b protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance