Mouse CLEC9A/CD370 protein (Recombinant) (C-hFc) (STJP020351)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse CLEC9A/CD370 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys57-Ile264) of mouse CLEC9A/CD370 (Accession #NP_001192292.1) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Mouse CLEC9A/CD370-C-hFc protein was developed in hek293 cells using the region Lys57-Ile264. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Store at-70 °C. This product is stable at ≤-70 °C for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Clec9a |
| Gene ID | 232414 |
| Uniprot ID | CLC9A_MOUSE |
| Immunogen | Recombinant Mouse CLEC9A/CD370 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys57-Ile264) of mouse CLEC9A/CD370 (Accession #NP_001192292.1) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Lys57-Ile264 |
| Immunogen Sequence | KFFQVSSLVLEQQERLIQQD TALVNLTQWQRKYTLEYCQA LLQRSLHSGTDASTGPVLLT SPQMVPQTLDSKETGSDCSP CPHNWIQNGKSCYYVFERWE MWNISKKSCLKEGASLFQID SKEEMEFISSIGKLKGGNKY WVGVFQDGISGSWFWEDGSS PLSDLLPAERQRSAGQICGY LKDSTLISDKCDSWKYFICE KKAFGSCI |
Additional Info
| Tissue Specificity | Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells. |
| Post Translational Modifications | Isoform 1: Not glycosylated. Isoform 4: N-glycosylated. |
| Function | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. |
| Protein Name | C-Type Lectin Domain Family 9 Member ADendritic Cell Natural Killer Lectin Group Receptor 1Cd Antigen Cd370 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | C-Type Lectin Domain Family 9 Member A proteinDendritic Cell Natural Killer Lectin Group Receptor 1 proteinCd Antigen Cd370 proteinClec9a proteinDngr-1 protein |
Information sourced from Uniprot.org