| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse CD40 (TNFRSF5)-protein was developed from hek293. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: | Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: | The activity was tested by the ability of immobilized recombinant mouse CD40 to bind Human CD40 Ligand with a linear range of 10-500 ng/ml NA |
| Gene Symbol: | Cd40 |
| Gene ID: | 21939 |
| Uniprot ID: | TNR5_MOUSE |
| Immunogen Region: | ECD |
| Immunogen: | Optimized DNA sequence encoding extracellular domain of Mouse CD40 including a C-terminal His tag was expressed in HEK293 cells. NA |
| Function | Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 5B-Cell Surface Antigen Cd40Bp50Cd40l ReceptorCd Antigen Cd40 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-5668541Reactome: -MMU-5676594 |
| Cellular Localisation | Isoform I: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Iii: Cell MembraneIsoform Iv: Cell MembraneIsoform V: Cell MembraneIsoform Ii: Secreted |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 5 proteinB-Cell Surface Antigen Cd40 proteinBp50 proteinCd40l Receptor proteinCd Antigen Cd40 proteinCd40 proteinTnfrsf5 protein |
Information sourced from Uniprot.org
