Mouse CD33 (Siglec-3) protein (Recombinant) (STJP000633)

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STJP000633
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD33 (Siglec-3)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: Cd33
Gene ID: 12489
Uniprot ID: CD33_MOUSE
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Mouse CD33 including an IgG1 Fc C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed on myeloid precursors in the bone marrow. In the peripheral blood, mostly expressed on granulocytes.
Post Translational Modifications Glycosylated. Phosphorylation is involved in binding to PTPN6 and PTPN11.
Function Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially binds sialic acid to the short O-linked glycans of certain mucins.
Protein Name Myeloid Cell Surface Antigen Cd33
Sialic Acid-Binding Ig-Like Lectin 3
Siglec-3
Cd Antigen Cd33
Database Links Reactome: R-MMU-198933
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Myeloid Cell Surface Antigen Cd33 protein
Sialic Acid-Binding Ig-Like Lectin 3 protein
Siglec-3 protein
Cd Antigen Cd33 protein
Cd33 protein
Siglec3 protein

Information sourced from Uniprot.org

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