Mouse CD163 protein (Recombinant) (N-His) (STJP009843)

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STJP009843
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD163-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Cd163
Gene ID: 93671
Uniprot ID: C163A_MOUSE
Immunogen Region: Met46-Ala261
Immunogen: Mus musculus (Mouse)
Post Translational Modifications A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs.
Function Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
Protein Name Scavenger Receptor Cysteine-Rich Type 1 Protein M130
Cd Antigen Cd163 Cleaved Into - Soluble Cd163
Scd163
Database Links Reactome: R-MMU-2168880
Cellular Localisation Soluble Cd163: Secreted
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Scavenger Receptor Cysteine-Rich Type 1 Protein M130 protein
Cd Antigen Cd163 Cleaved Into - Soluble Cd163 protein
Scd163 protein
Cd163 protein
M130 protein

Information sourced from Uniprot.org

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